In Manhattan, uptown means north (more precisely north-northeast, which is the direction the island and its street grid system is oriented) and downtown means south (south-southwest)
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To the north, the Harlem River divides Manhattan Island from Bronx and the mainland United States. Several small islands are also part of the borough of Manhattan, including Randall’s Island, Wards Island, and Roosevelt Island in the East River, and Governors Island and Liberty Island to the south in New York Harbor.